U.S. Department of Energy

Pacific Northwest National Laboratory

Lee Ann McCue

Lee Ann McCue
(509) 375-2912
Principal Investigator

Dr. McCue's early research focused on the development and application of comparative genomics methods for studies of transcription regulation in bacteria. Her research pioneered the phylogenetic footprinting approach for predicting transcription factor binding sites de novo using multiple bacterial genomes, and contributed to a number of algorithmic advances to the Gibbs sampling technique for multiple sequence alignment. Her research at PNNL has expanded to include the analysis of microbial populations and metagenomes for microbial ecology studies, and the application of high performance computing techniques to handle the quantity of data being generated by current sequencing technologies.

Research Interests

  • comparative genomics and metagenomics
  • sequence alignment
  • transcription regulation

Education and Credentials

  • B.S. Microbiology and Biophysics, Iowa State University, 1986
  • Ph.D. Microbiology, The Ohio State University, 1994

Affiliations and Professional Service

  • Member of the American Society for Microbiology
  • Member of the International Society for Computational Biology

Awards and Recognitions

  • 2008 Winner, Supercomputing High Performance Computing Analytics Challenge

For more information, go to FCSD staff information.


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