U.S. Department of Energy

Pacific Northwest National Laboratory

Signature Discovery in the Fecal Microbiome

Advancing the understanding of microbiome conditions in the context of the most commonly performed bariatric surgery in the United States, the Roux-en-Y (RYGB) gastric bypass. A microbiome is "the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space.” The human gut microbiome has been noted to function as a “virtual” body organ.


Subject group identification algorithms that better incorporate available information and assess uncertainties are needed. This research will speed fecal microbiome research and similar metabolomics research to become more efficient, by giving quicker methods of visualizing and analyzing big data sets with a large number of observed variables and consisting of multiple data types; and more economical, by determining the least amount of data required to provide a reliable discrimination of subject groups.

This is important for:

  • National Institutes of Health (NIH): metabolomics data analysis relevant to human health, particularly for large epidemiological studies
  • DOE Office of Biological and Environmental Research (DOE-BER): studies of organisms (bacteria, fungi, plants) relevant to such areas as biofuels and bioproducts production, carbon cycling and bioremediation.
Project Staff: 
Nancy Isern, David Hoyt, Tom Metz, Landon Sego, Lisa Bramer, Trenton Pulsipher
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